Journal of Medicinal Materials, 2025, Vol. 30, No. 5 (327 - 332)

ALKALOIDS ISOLATED FROM CRINUM VIVIPARUM (LAM.)
R. ANSARI & V. J. NAIR AND THEIR BIOLOGICAL ACTIVITIES

Vu Thi Trang¹, Ngo Viet Duc², Pham Van Cong³, Ngo Van Hieu², Nguyen Tien Dat²,
Do Thanh Tuan⁴, Dang Viet Hau³, Nguyen Thi Thanh⁵, Hoang Le Tuan Anh², Le Quynh Lien^6,*

¹Institute of Biology, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam;

²Center for High Technology Research and Development (CHTD), VAST, Hanoi, Vietnam;

³National Institute of Medicinal Materials (NIMM), Hanoi, 11022, Vietnam;

⁴Thai Binh University of Medicine and Pharmacy, Hung Yen, Vietnam;

⁵Institute for Regional Research and Development, Ministry of Science and Technology, Vietnam;

⁶Institute of Chemistry, VAST, Hanoi, Vietnam

*Corresponding author: lienle@vast.vn

Summary

Five known alkaloids, lycorine (1), 2-O-acetyllycorine (2), (+)-vittatine (3), 8-demethyl-3-oxomaritidine (4), and (-)-maritinamine (5) were isolated from the Vietnamese medicinal plant Crinum viviparum (Lam.) R.Ansari & V.J.Nair. Their structures were identified by spectroscopic methods and by comparison with literature data. Except for lycorine, the remaining compounds were reported for the first time from Vietnamese C. viviparum. All five alkaloids were evaluated for nitric oxide (NO) suppression and cytotoxicity. Compounds 3 and 4 moderately inhibited NO production, while compounds 1, 2, and 4 showed cytotoxic activity against the HepG2 and LNCaP cell lines (IC₅₀ = 7.02 – 72.25 μM). These results highlight C. viviparum as a promising source of bioactive alkaloids with potential anti-inflammatory and anticancer properties.

Keywords: Crinum viviparum; Amaryllidaceae alkaloids; Anti-inflammatory activity; Cytotoxicity.

(Nguồn tin: )