Journal of Medicinal Materials, 2025, Vol. 30, No.3 (pp. 152 - 156)

CYTOTOXIC ACTIVITY OF XANTHONES FROM THE TWIGS

AND LEAVES OF CRATOXYLUM COCHINCHINENSIS (LOUR.) BLUME

Nguyen Manh Khoa¹, Trinh Thi Quynh Anh², Nguyen Thi Kim Oanh³, Nguyen Thi Thu¹,

Nguyen Tra My¹, Ngo Thi Thuy⁴, Nguyen Hung Son⁵, Nguyen Manh Tuyen², Do Thi Ha^1,*

¹National Institute of Medicinal Materials (NIMM), Hanoi, 11022, Vietnam;

²Hanoi University of Pharmacy, Hanoi, Vietnam;

³Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam;

⁴Hanoi Medical University Hospital, Vietnam;

⁵Military Institute of Traditional Medicine, Hanoi, Vietnam

*Corresponding author: hado.nimms@gmail.com

Summary

This study aimed to isolate and identify bioactive compounds from the ethyl acetate extract of Cratoxylum cochinchinensis twigs and leaves. As a result, five xanthones were obtained and structurally characterized as 1,8-dihydroxy-3-methoxy-6-methylxanthone (1), cochinchinone A (2), 1,3,7-trihydroxy-2,4-diisoprenylxanthone (3), α-mangostin (4), and 1,3,5,6-tetrahydroxy-7-isoprenylxanthone (5). Notably, compounds 1 and 5 were isolated for the first time from C. cochinchinensis. Furthermore, the cytotoxic activity of these compounds was evaluated in vitro against three cancer cell lines (A549, MCF-7, and HepG2). Among them, compounds 2-4 exhibited cytotoxic activities against all tested cell lines, with IC₅₀ values ranging from 10.24 to 16.86 µM. Meanwhile, compound 5 showed selective activity against MCF-7 and HepG2, with IC₅₀ values of 13.55 ± 0.74 and 16.69 ± 0.81 µM, respectively.

Keywords: Cratoxylum cochinchinensis; Xanthones; Cytotoxic activity.

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