Journal of Medicinal Materials, 2024, Vol. 29, No. 6 (pp. 340 - 346)
DETERMINATION OF STRYCHNINE AND BRUCINE BY HPLC
FOR BETTER QUALITY CONTROL OF STRYCHNI SEMEN
Vu Ngan Binh1, Pham Thi Thanh Ha1, Dang Thi Ngoc Lan1,
Do Thi Bich Diep1, Nguyen Quynh Chi1, Do Quyen1*,
Huynh Truc Thanh Ngoc2, Nguyen Thi Ngoc Dung2,
Sysay Palamy3, Chiobouaphony Phakeovilay3
1Hanoi University of Pharmacy, Vietnam; 2Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam; 3Faculty of Pharmacy, University of Health Sciences Laos
*Corresponding author: doquyen@hup.edu.vn
(Received September 28th, 2024)
Summary
Determination of Strychnine and Brucine by HPLC for Better Quality Control of Strychni semen
In the 5th Vietnamese pharmacopoeial monograph for Strychni semen, 19 species of the genus Strychnos are accepted as medicinal material, and the quality of Strychni semen varies significantly. In this study, a high-performance liquid chromatographic (HPLC) method is used to identify and quantify strychnine and brucine in 12 Strychni semen samples collected from different regions in Vietnam and Laos. Based on the alkaloid content in combination with the morphological properties of the analyzed samples, some comments on measures to improve quality control of Strychni semen were suggested for the Vietnam market.
Keywords: Strychnine, Brucine, Strychni semen, HPLC, Quality control.
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