Ấn phẩm

Isolation, Structural Determination of Flavone Glycosides from the Leaves of Syzygium cumini and their Cytotoxic Evaluation (Tạp chí Dược liệu, tập 29, số 6/2024))

Journal of Medicinal Materials, 2024, Vol. 29, No. 6 (pp. 323 - 329)

 

ISOLATION, STRUCTURAL DETERMINATION OF

FLAVONE GLYCOSIDES FROM THE LEAVES OF SYZYGIUM CUMINI

AND THEIR CYTOTOXIC EVALUATION

Nguyen Thi Van,1,2 Nguyen Thi Hue1, Vu Van Nam1, Trinh Thi Thanh Van1, Nguyen Thuy Linh1, Tran Thu Huong2, Cao Duc Tuan3, Pham Van Cuong1, *, Doan Thi Mai Huong1 ,*

1Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST),

Hanoi, Vietnam;

2Hanoi University of Science and Technology, Hanoi, Vietnam;

3Hai Phong University of Medicine and Pharmacy, Hai Phong, Vietnam

*Corresponding author: phamvc@imbc.vast.vn; huongdm@imbc.vast.vn

(Received August 14th, 2024)

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Isolation, Structural Determination of Flavone Glycosides from the Leaves of Syzygium cumini

and their Cytotoxic Evaluation

Five flavone glycosides were isolated from the EtOAc and aqueous extracts of Syzygium cumini (L.) Skeels leaves. Their chemical structures were elucidated as quercetin 3-O-neohesperidoside (1), rutin (2), quercetin 3-O-α-L-rhamnopyranoside (3), kaempferol 3-O-neohesperidoside (4), and afzelin (5) on the basis of detailed analyses of the 1D and 2D NMR spectroscopic data and in comparison with the literature data. All isolated compounds (1-5) were estimated for their cytotoxicity against KB, MCF-7, HepG2, and A549 human cancer cell lines. Unfortunately, these compounds were inactive against all four tested human cancer cell lines at the concentration of 128 µg/mL. To the best of our knowledge, compounds 1 and 4 were first reported from the Syzygium genus, while compounds 3 and 5 were isolated from the leaves of Syzygium cumini for the first time.

Keywords: Syzygium cumini, Myrtaceae, Flavone glycosides, Quercetin, Kaempferol, Cytotoxicity.

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