Journal of Medicinal Materials, 2025, Vol. 30, No. 2 (pp. 92 - 97)

PHENOLIC CONSTITUENTS FROM THE LEAVES

OF CAMELLIA HAKODAE NINH

WITH THEIR α-GLUCOSIDASE INHIBITORY ACTIVITY

Pham Hai Yen¹, Nguyen Thi Cuc², Nguyen Huy Hoang¹, Phan Van Kiem¹,
Do Thi Ha³, Bui Huu Tai^1,*

¹Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam;

²Hanoi Irradiation Centre, Ministry of Science and Technology of Vietnam, Hanoi, Vietnam;

³National Institute of Medicinal Materials (NIMM), Hanoi, 12110, Vietnam

*Corresponding author: bhtaiich@gmail.com

Summary

Phenolic Constituents from the Leaves of Camellia hakodae Ninh with their α-Glucosidase Inhibitory Activity

Six phenolic compounds, including camelliquercetiside D (1), tsubakioside A (2), stachyanthuside A (3), rutin (4), kaempferol 3-rutinoside (5), and kaempferol 3-O-β-D glucopyranoside (6), were isolated from the methanol extract of Camellia hakodae Ninh. Their chemical structures were identified by HR-ESI-MS, 1D and 2D NMR spectra and compared with the published data in the literature. The compounds were screened for their α-glucosidase inhibitory activity. Compounds 1, 2, 4-6 showed significant inhibition with IC₅₀ values of 35.41 ± 0.02, 15.43 ± 0.39, 10.64 ± 0.23, 17.21 ± 0.34, and 19.42 ± 0.25 µM, respectively, compared to that of positive control, acarbose, which showed IC₅₀ value of 47.10 ± 1.40 µM.

Keywords: Camellia hakodae Ninh; Flavonoid glycoside; α-Glucosidase inhibitory activity.

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