Journal of Medicinal Materials, 2025, Vol. 30, No. 2 (pp. 67 - 73)

PHENOLIC CONSTITUENTS OF TWIGS AND LEAVES

OF WIKSTROEMIA INDICA (L.) C.A. MEY.

AND THEIR EFFECTS ON LPS-INDUCED IL-1β AND IL-10 CYTOKINE PRODUCTION IN RAW 264.7 CELL LINES

Nguyen Van Lieu^1,2, Nguyen Van Thu², Nguyen Thi Hong Anh¹, Vu Thi Diep¹,

Nguyen Hung Son³, Tran Thi Hien^4,5, Hoang Viet Dung², Ngo Thi Duyen⁵, Do Thi Ha^1,*

¹National Institute of Medicinal Materials (NIMM), Hanoi, 11022, Vietnam;

²Institute of Pharmaceutical Training, Vietnam Military Medical University, Hanoi, Vietnam;

³Military Institute of Traditional Medicine, Hanoi, 11718, Vietnam;

⁴Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine,

Lund University, Lund, Sweden;

⁵Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam

*Corresponding author: hado.nimms@gmail.com

Summary

Phenolic Constituents of Twigs and Leaves of Wikstroemia indica (L.) C.A. Mey. and their Effects
on LPS-Induced IL-1β and IL-10 Cytokine Production in RAW 264.7 Cell Lines

Five phenolic compounds, including methyl 4-hydroxybenzoate (1), syringin (2), genkwanin (3), kaemferol-3-O-rhamnoside (4), and yuankanin (5), were isolated from the 70% EtOH extract of W. indica twigs and leaves. Their structures were identified using nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS) datawith compound 2 being reported for the first time from this plant. The compounds were evaluated for their effects on IL-1β and IL-10 cytokine production in LPS-induced RAW 264.7 macrophages and 3 showed considerably inhibitory activity against IL-1β with an IC₅₀ value of 18.8 ± 2.46 µM.

Keywords: W. indica; Phenolics; Flavonoids; IL-1β; IL-10.

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