Journal of Medicinal Materials, 2025, Vol. 30, No. 6 (394 - 402)

PHENOLICS FROM THE BRANCHES AND LEAVES

OF EHRETIA ASPERULA ZOLL. & MORITZI COLLECTED IN VIETNAM

Nguyen Phuong Trang^1,2, Nguyen Thi Thu^1,*, Le Hong Van Anh¹, Do Hoang Anh¹,

Pham Thi Hien¹, Dao Viet Quoc¹, Hoang Thai Hoa³, Nguyen Canh Tuan Anh⁴, Vu Thuy Dung⁴, Do Thi Ha¹, Le Nguyen Thanh¹, Nguyen Hoang Tuan²

¹National Institute of Medical Materials (NIMM), Hanoi 11018, Vietnam;

²Hanoi University of Pharmacy, Hanoi;

³Faculty of Pharmacy, University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam;

⁴Haiphong University of Medicine and Pharmacy, Haiphong, Vietnam

*Corresponding author: Tvianeythudkh99@gmail.com

Summary

Six compounds, including 3,4-dihydroxybenzaldehyde (1), caffeic acid (2), rosmarinic acid (3), salvianolic acid B (4), benzyl β-D-glucopyranoside (5), and astragalin (6), were isolated from the ethyl acetate extract of E. asperula. Their structures were elucidated based on extensive nuclear magnetic resonance spectroscopy (NMR) data and mass spectrometry (MS), as well as by comparison with published literature. Among them, compounds 1 and 5 are reported for the first time from the Ehretia genus. These compounds were isolated to identify key chemical markers for evaluating the quality of E. asperula in Vietnam.

Keywords: Ehretia asperula; Phenolics; Rosmarinic acid, Salvianolic acid B.

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