Journal of Medicinal Materials, 2025, Vol. 30, No. 2 (pp. 121 - 124)

THE INHIBITORY EFFECTS ON ACETYLCHOLINESTERASE

AND α-GLUCOSIDASE OF SOME COMPOUNDS

FROM MEDICINAL PLANTS IN VIETNAM

Nguyen Khac Tiep¹, Doan Thi Ai Nghia², Nguyen Thi Hoai², Phung Thanh Huong^1,*

¹Faculty of Biotechnology, Hanoi University of Pharmacy, Vietnam;

 ²Faculty of Pharmacy, University of Medicine and Pharmacy, Hue University, Vietnam

*Corresponding author: huongpt@hup.edu.vn

Summary

The Inhibitory Effects on Acetylcholinesterase and α-Glucosidase of some Compounds
from Medicinal Plants in Vietnam

The study evaluates the inhibitory potential of several natural compounds on two enzymes, acetylcholinesterase and α-glucosidase, which are associated with Alzheimer's disease and diabetes. Six compounds from various medicinal plants in Vietnam, with a range of tested concentrations from 512 to 0.032 µg/mL, were used for bioassays, demonstrating varying degrees of enzyme inhibition. Specifically, for acetylcholinesterase, alpha- and beta-amyrin, 2H-chromen-2-one, and lupeol exhibited IC₅₀ values of 348.70, 300.07, and 135.92 µg/mL, respectively. All six compounds showed IC₂₅ values ranging from 65 to approximately 245 µg/mL. For α-glucosidase, GC1 and UGC9 showed IC₅₀ values of approximately 69 and 295 µg/mL, respectively. The remaining compounds did not exhibit IC₅₀ or IC₂₅ values at the maximum tested concentration of 512 µg/mL. None of the six test samples caused hemolysis at the maximum tested concentration (2048 µg/mL), suggesting their safety. These results highlight the promising potential of these natural compounds for further research and therapeutic applications.

Keywords: Acetylcholinesterase; α-Glucosidase; Inhibitory activity.

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