Summary
Cytotoxic Activities of Flavonoids Isolated from the
Buds of Cleistocalyx operculatus Against some Cancer cell Lines
Fourteen flavonoids 1-14 were isolated from the buds of the plant Cleistocalyx operculatus by repeated column chromatography. Their structures were identified on the basis of physicochemical and spectroscopic analyses. Eleven compounds were tested for their cytotoxic activities against some human cancer cell lines. The most interesting finding is that compound 6 (5-hydroxy-7-methoxy-6,8-dimethylflavanone) exhibited significantly inhibitory effects against Hela cells with an IC50 value of 1.3 mg/ml.
Keywords: Cleistocalyx operculatus, flavonoid, cytotoxicity, cancer cell, 5-hydroxy-7-methoxy-6,8-dimethylflavanone.
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