Screening of Vietnamese Medicinal Plants for Stimulatory Effect

on Osteoblastic MC3T3-E1 Cell Growth

Many plant-derived substances have estrogenic activities. Due to their ability to bind to the estrogen receptor, these compounds have the potential to counteract the deleterious effects of estrogen deficiency on bone. In this study, traditional Vietnamese medicinal plants were screened for their stimulatory effects on the growth of osteoblastic MC3T3-E1 cells. As a result of screening, the extracts of Strobilanthes cusia (142%), Celatrus sp. (123%), Camellia sinensis (116%) and Trichosanthes kirilowii (117%) had significantly high viability enhancing effect compared to control at 30 mg/mL (P < 0.05). The extracts of Bousingonia mekongense (123%) and Goniothalamus vietnamensis (116%) also significantly stimulated the growth of MC3T3-E1 cells at 3 and 0.3 mg/ml, respectively (P < 0.05). These results suggest that these Vietnamese plants may play important physiological roles in the prevention of postmenopausal osteoporosis.

Key words: Vietnamese plants, Strobilanthes cusia, osteoblastic MC3T3-E1 cells.

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