Journal of Medicinal Materials, 2023, Vol. 28, No. 6 (pp. 343 - 351)
CHEMICAL COMPOSITION, ANTI-INFLAMMATORY AND CYTOTOXIC ACTIVITIES OF ESSENTIAL OILS
FROM ZANTHOXYLUM MYRIACANTHUM WALL. EX HOOK. F. FRUITS, LEAVES AND STEMS COLLECTED IN LAM DONG PROVINCE
Trinh Thi Diep1, *, Luong Van Dung1, Phung Van Trung2, Do Thi Thao3, Nguyen Thi Hoai4, Nguyen Thi To Uyen1, Tran Thi Hoai Linh1, Huynh Thanh Truc1, Le Thi Thanh Tran1, Vu Thi Bao Ngoc1
1Dalat University, Vietnam; 2Institute of Applied Material Science, Vietnam Academy of Science and Technology;
3Institute of Biotechnology, Vietnam Academy of Science and Technology,
4Hue University of Medicine and Pharmacy, Hue University
*Corresponding author: dieptt@dlu.edu.vn
(Received August 15th, 2023)
Summary
Chemical Composition, Anti-Inflammatory and Cytotoxic Activities of Essential Oils from Zanthoxylum myriacanthum Wall. ex Hook. f. Fruits, Leaves and Stems Collected in Lam Dong Province
Essential oils extracted by hydrodistillation from fruits, leaves, and stems of Z. myriacanthum collected in Bidoup-Nui Ba National Park, Lam Dong province, Vietnam were investigated for their chemical composition and bioactivity. 51 compounds were identified in the fruit oil (ZMFR), of which p-cymen-8-ol (24.9%) and β-pinene (24.3%) were the most abundant. The leaf oil (ZML) contained 32 identified constituents, mainly ρ-methyl-acetophenone (29.9%), α-terpineol (17.0%), ar-curcumene (9.5%), (E)-carpacin (7.7%), 2-undecanone (6.6%) and 2-tridecanone (5.9%). The stem oil (ZMS) consisted of 23 compounds, the major ones being ar-curcumene (44.6%), terpinen-4-ol (13.2%), (1R,2R,4R)-4-(2-hydroxypropan-2-yl)-1-methylcyclohexane-1,2-diol (8.8%) and α-terpineol (8.4%). ZMFR exhibited moderate NO production inhibition in macrophage RAW 264.7 cells with an IC50 value of 42.35 ± 2.63 mg/mL. ZMFR and ZML showed moderate cytotoxic effects on SK-LU-1, MCF-7, and HepG2 cancer cell lines with the IC50 values ranging from 50.97 ± 4.07 to 93.78 ± 3.67mg/mL. ZMS was cytotoxic against HepG2 (IC50 = 69.84 ± 4.71 mg/mL) and MCF-7 (IC50 = 89.28 ± 5.50 mg/mL), and showed minimal effect on SK-LU-1. The anti-inflammatory and cytotoxic activities of Z. myriacanthum essential oils were evaluated and reported for the first time.
Keywords: Zanthoxylum myriacanthum, Essential oil, GC-MS, Anti-microbial activity, NO inhibition, Cytotoxicity.
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