Journal of Medicinal Materials, 2021, Vol. 26, No. 3 (pp. 138 - 143)
PHENOLIC COMPOUNDS FROM α-GLUCOSIDASE
INHIBITORY ACTIVE FRACTIONS OF HOMONOIA RIPARIA LOUR.
Chung Khanh Linh1, Pham Thao Nguyen1, Nguyen Minh Dat1,
Nguyen Le Hoang Son2, Nguyen Thi Cam3, Hoang Ngoc Cuong2, Le Van Huan2,*
1Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam;
2Faculty of Biotechnology, Binh Duong University, Vietnam;
3Faculty of Pharmacy, Binh Duong Medical College, Vietnam
*Corresponding author: lvhuan@bdu.edu.vn
(Received May 30th, 2021)
Summary
Phenolic Compounds from a-Glucosidase Inhibitory Active Fractions of Homonoia riparia Lour.
The ethyl acetate (EtOAc) fraction from an ethanol extract of Homonoia riparia leaves (Euphorbiaceae) exhibited in vitro inhibitory activity on α-glucosidase, one of the key enzymes that are the therapeutic target for the treatment of diabetes mellitus. An intensive phytochemical study of the EtOAc fraction led to the isolation of quercetin (1), myricetin (2), ethyl gallate (3), gallic acid (4) and myricitrin (5). Their structures were elucidated by spectroscopic methods (including MS, 1D, and 2D-NMR) and by comparison with published data. These compounds, for the first time, have been isolated from H. riparia leaves collected in Quang Ngai Province, Vietnam.
Keywords: Homonoia riparia Lour., NMR, α-Glucosidase inhibitor, Plant extracts, Phenolic.
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