Summary

Amurensin G Inhibited UVA-Induced Cyclooxygenase-2 Expression in JB6 Cl41 Cells

Overexpression of cyclooxygenase-2 (COX-2) leads to prostanoid formation in skin tissue, disturbs the balance between proliferation and apoptosis, and subsequently promotes tumorigenesis. In this work, amuresin G showed protection effects on JB6 Cl41 mouse epidermal cells exposed to UVA, which induces COX-2 protein expression and prostaglandin E2 production in an energy-dependent manner. These overexpressions were significantly decreased by amurensin G. Additionally, the increased COX-2 gene transcription in response to UVA was preceded by activation of the transcription factors nuclear factor-κB (NF-κB), cAMP response element-binding protein (CREB), CCAAT/enhancer-binding proteins α and β (C/EBPα and C/EBPβ) and c-Jun/activator protein-1 (AP-1). Amurensin G treatment abolished the activation of NF-κB, CREB, and C/EBP by UVA irradiation. These results suggest that amurensin G inhibits UVA-induced COX-2 expression in JB6 Cl41 cells.

Keywords: Amurensin G, UVA, COX-2.                  

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