Summary

Anti-Diarrheal Effect of Pseuderanthemum palatiferum (Nees) Radlk. in Mouse Model

This research aimed to investigate the anti-diarrheal effect of ethanol extract of P. palatiferum at doses p.o. of 100, 200, 400, 600 and 800 mg/kg body weight on castor oil-induced diarrhea, small intestinal transit and intra-luminal fluid accumulation secretion in mice. The results showed that the ethanol extract of P. palatiferum at a dose p.o. of 800 mg/kg body weight significantly exhibits the most effect against diarrhea, reducing the number of wet stools (inhibition percentage of 41.53%), inhibiting up to 42.01%, in small intestinal transit and eliminating intra-luminal fluid accumulation up to 76.01%. These findings provide scientific evidence that the ethanol extract of P. palatiferum possesses anti-diarrheal property.

Keywords: Pseuderanthemum palatiferum, Anti-diarrheal, Castor oil, Intestinal transit, Intra-luminal fluid.

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