Flavonoid and Sterol Glycosides Isolated from Aconitum carmichaelii (Dexb.)
Growing in Ha Giang Province
Vu Duc Loi1*, Nguyen Tien Vung2, Nguyen Thuong Dong3,
Nguyen Minh Khoi3, Do Thi Ha3
1School of Medicine and Pharmacy, Vietnam National University, Hanoi; 2 National Institute of Forensic Medicine; 3National Institute of Medicinal Materials, Hanoi, Vietnam
*Corresponding author: Ducloi82@gmail.com
(Received September 04th, 2013)
Summary
Two flavonol glycosides: quercetin 3-O-α-L-rhamnopyranoside (1), quercetin 3-O-β-D-galactopyranoside (2) and β-sitosterol 3-O-β-D-glucopyranoside (3) were isolated from the leaves of Aconitum carmichaelii Dexb. Their structures were elucidated by spectroscopic methods, including IR, MS and NMR. Compounds 1 and 2 were isolated from the first time in A. carmichaelii and compound 3 was isolated from the first time in the leaves of this plant.
Keywords: Aconitum carmichaelii; Quercitrin; Hyperoside; Daucosterol.
1. Introduction
The Aconitum L. genus which is mainly characterized by the presence of highly toxic diterpene alkaloids has been traditionally used in China as source of arrow poison for 2000 years. The alkaloid composition of different European Aconitum species was analysed, particularly qualitative and quantitative analysis of diterpenoid alkaloids presence in A. carmichaelii Dexb. have been studied during its onthogenetic cycle. In Vietnam, Bui Hong Cuong has been reported to chemical compositions including alcaloids, acid amin, free sugars, organic acids. of A. carmichaelii Debx. var.carmichaelii collected in Sapa. Its rhizomes contain fatty acid, sterol and its stems contain carotenoids, its leaves and flowers present carotenoids, sterols, flavonoids. Several alcaloids named karacolin,benzoylmesaconin.. also reported in this study [1]. In the last years the study of Aconitum genus was directed to the other secondary metabolites such as flavonoids. The flavonol composition of the aerial parts of A. jaluense, A. pseudolaeve and A. chiisanense have been reported [7]. Regarding the European species, the flowers of A. paniculatum have shown the presence of three new flavonol glycosides [4]. However, there have been no reports of flavonoid compositions from A. carmichaelii collected in Ha Giang province, Vietnam. In this paper describes the isolation and structure elucidation of compounds isolated from the leaves of Aconitum carmichaelii Dexb.
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