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FLAVONOID AND STEROL GLYCOSIDES ISOLATED FROM ACONITUM CARMICHAELII (DEXB.) GROWING IN HA GIANG PROVINCE

FLAVONOID AND STEROL GLYCOSIDES ISOLATED FROM ACONITUM CARMICHAELII (DEXB.) GROWING IN HA GIANG PROVINCE

Flavonoid and Sterol Glycosides Isolated from Aconitum carmichaelii (Dexb.)

Growing in Ha Giang Province 

Vu Duc Loi1*, Nguyen Tien Vung2, Nguyen Thuong Dong3,

Nguyen Minh Khoi3, Do Thi Ha3

1School of Medicine and Pharmacy, Vietnam National University, Hanoi; 2 National Institute of Forensic Medicine; 3National Institute of Medicinal Materials, Hanoi, Vietnam

*Corresponding author: Ducloi82@gmail.com

(Received September 04th, 2013)

Summary

Flavonoid and Sterol Glycosides Isolated from Aconitum carmichaelii (Dexb.)

Growing in Ha Giang Province 

Two flavonol glycosides: quercetin 3-O-α-L-rhamnopyranoside (1), quercetin 3-O-β-D-galactopyranoside (2) and β-sitosterol 3-O-β-D-glucopyranoside (3) were isolated from the leaves of Aconitum carmichaelii Dexb. Their structures were elucidated by spectroscopic methods, including IR, MS and NMR. Compounds           1 and 2 were isolated from the first time in A. carmichaelii and compound 3 was isolated from the first time in the leaves of this plant. 

Keywords: Aconitum carmichaeliiQuercitrin; Hyperoside; Daucosterol.

 

1. Introduction

The Aconitum L. genus which is mainly characterized by the presence of highly toxic diterpene alkaloids has been traditionally used in China as source of arrow poison              for 2000 years. The alkaloid composition           of different European Aconitum species           was analysed, particularly qualitative and quantitative analysis of diterpenoid alkaloids presence in A. carmichaelii Dexb. have been studied during its onthogenetic cycle. In Vietnam, Bui Hong Cuong has been reported to chemical compositions including alcaloids, acid amin, free sugars, organic acids. of A. carmichaelii Debx. var. carmichaelii collected in Sapa. Its rhizomes contain fatty acid, sterol and its stems contain carotenoids, its leaves and flowers present carotenoids, sterols, flavonoids. Several alcaloids named karacolin, benzoylmesaconin.. also reported in this study [1]. In the last years the study of Aconitum genus was directed to the other secondary metabolites such as flavonoids. The flavonol composition of the aerial parts of A. jaluense, A. pseudolaeve and A. chiisanense have been reported [7]. Regarding the European species, the flowers of A. paniculatum have shown the presence of three new flavonol glycosides [4]. However, there have been no reports of flavonoid compositions from A. carmichaelii collected in Ha Giang province, Vietnam. In this  paper describes the isolation and structure elucidation of compounds  isolated from the leaves of Aconitum carmichaelii Dexb.

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