Journal of Medicinal Materials, 2017, Vol. 22, No. 3 (pp. 311 - 315)
HEPATOPROTECTIVE AND ANTI-INFLAMMATORY EFFECTS OF THE AQUEOUS EXTRACT FROM CHLORANTHUS JAPONICUS SIEB.
Do Thi Oanh1, Pham Thi Nguyet Hang2,*, Le Viet Dung2, Pham Thanh Ky3
1Central Traditional Medicine Hospital;
2National Institute of Medicinal Materials, Hanoi, Vietnam;
3Hanoi University of Pharmacy; 4Vietnam University of Traditional Medicine
*Corresponding author: pnhang2004@yahoo.com
(Received March, 31st, 2017)
Summary
Hepatoprotective and Anti-Inflammatory Effects of the Aqueous Extract from Chloranthus japonicus Sieb.
Chloranthus japonicus Sieb. (CJ) has been used as a medicine for a long time. Our previous study has proved the hepatoprotective, anti-inflammatory effects of the aerial parts of Chloranthus japonicus Sieb. extract in experimental animals. In this study, the hepatoprotective and anti-inflammatory effects of the underground parts of the CJ water extract was continued. The results showed that 4.0 and 12.0 g/kg of the CJ water extract showed the hepatoprotective effect on a paracetamol-induced liver injury model. It also exhibited a chronic anti-inflammatory effect on amiant-induced granuloma in mice. At the doses of 2.8 and 8.4 g/kg, the CJ water extract did not show the acute anti-inflammatory effect on carrageenan-induced paw edema and carrageenan/formaldehyde-induced peritonitis in rats.
Keywords: Chloranthus japonicus Sieb.; Hepatoprotective, Anti-inflammation effects, Experimental animals.
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