Journal of Medicinal Materials, 2017, Vol. 22, No. 3 (pp.146-151)
LIGNAN AND FLAVONOIDS FROM AERIAL PARTS
OF AGRIMONIA PILOSA LEDEB.
Nguyen Van Linh1, Duong Thi Hai Yen2, Hoang Le Tuan Anh2,*, Vu Manh Hung3,
Nguyen Thi Mai4, Pham Thanh Ky5,*
1Military Institute of Traditional Medicine, Hanoi, Vietnam;
2Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST);
3Vietnam Military Medical University, Ha Dong, Hanoi, Vietnam;
4University of Transport and Communications, Hanoi, Vietnam;
5National Institute of Medicinal Materials, Hanoi, Vietnam
*Corresponding author: firstname.lastname@example.org
(Received April 2017)
Lignan and Flavonoids from Aerial Parts of Agrimonia pilosa Ledeb.
By chromatographic separation, a lignan glycoside, (+) isolariciresinol-3a-O-b-D-glucopyranoside (1), and three known flavonoids, naringenin 7-O-β-D-glucopyranoside (2), leucoside (3) and kaempferol (4) were isolated from the methanol extract of the aerial parts of Agrimonia pilosa. Their structures were determined by 1D-, 2D-NMR spectroscopic analyses and in comparison with the reported data. Compound 2 exhibited weak anti-inflammatory effect toward inhibition of NO production with IC50 value of 91.07 µg/ml. To our best knowledge, compounds 1 - 3 were isolated from genus Agrimonia for the first time.
Keywords: Agrimonia pilosa, Isolariciresinol-3a-b-D-glucopyranoside, Naringenin 7-O-β-D-glucopyranoside, Leucoside, Nitric Oxide (NO).
(Nguồn tin: Tạp chí Dược liệu - Viện Dược liệu)