Tạp chí

Hepatoprotective Activity of Cultivated Vietnamese Ginseng on Oxidative Stress-Induced Liver Injury in Mice

Journal of Medicinal Materials, 2017, Vol. 22, No. 3 (pp. 183-189)



Hepatoprotective activity of cultivated

Vietnamese ginseng

on oxidative stress-induced liver injury in mice

Duong Hong To Quyen1, Nguyen Thi Thu Huong2,*, Nguyen Thuy Viet Phuong3,

Nguyen Minh Duc3,4

1Hospital of Traditional Medicine at Ho Chi Minh City, Vietnam;

2Research Center of Ginseng and Medicinal Materials, National Institute of Medicinal Materials,

Ho Chi Minh City, Vietnam;

3Faculty of Pharmacy, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam;

4Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam

*Corresponding author: huongsam@hotmail.com

(Received April, 11th, 2017)


Hepatoprotective Activity of Cultivated Vietnamese Ginseng

on Oxidative Stress-Induced Liver Injury in Mice

In this study, the effects of the underground part of cultivated Vietnamese ginseng extract (VGE) on hepatotoxicity were investigated. Carbon tetrachloride (CCl4), cyclophosphamide (Cy) or ethanol was applied to cause liver injury in Swiss albino mice. Plasma aspartate transaminase (AST), plasma alanine transaminase (ALT), hepatic malondialdehyde (MDA), and hepatic glutathione (GSH) levels were determined. VGE and Panax ginseng extract (PGE) were treated at the doses of 100 mg/kg and 200 mg/kg in mice. Silymarin (100 mg/kg) was used as a reference drug. The results showed that the plasma AST and ALT levels increased significantly in CCl4 and ethanol-treated control groups. An increase in hepatic MDA level and a decrease in hepatic GSH level were revealed in CCl4-, Cy-, and ethanol-treated control groups, indicating oxidative damage in liver. Oral treatment with VGE as well as PGE prevented an increase in plasma AST, ALT, and hepatic MDA levels. In parallel, VGE and PGE significantly elevated hepatic GSH levels. The results showed that cultivated Vietnamese ginseng extract might be developed as a hepatoprotective natural product with an oxidative stress-related mechanism.

Keywords: Cultivated Vietnamese ginseng, Hepatoprotective effect, Carbon tetrachloride, Cyclophosphamide, Ethanol.


(Nguồn tin: Tạp chí Dược liệu - Viện Dược liệu)