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Cytotoxic Effect of Alkaloids from Euphorbia thymifolia Burm. Grown in Vietnam

Journal of Medicinal Materials, 2017, Vol. 22, No. 3 (pp. 172-178)

CYTOTOXIC EFFECT OF ALKALOIDS FROM

EUPHORBIA THYMIFOLIA BURM. GROWN IN VIETNAM

Nguyen Tien Vung¹^,*, Vu Duc Loi²_,Bui Thanh Tung², Pham Giang Nam²

¹National Institute of Forensic Medicine, Hanoi, Vietnam

²School of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam

*Corresponding author: tienvung@gmail.com

(Received March, 16^th, 2017)

Summary

Cytotoxic Effect of Alkaloids from Euphorbia thymifolia Burm. Grown in Vietnam

From 96% ethanol extract of Euphorbia thymifolia Burm. collected in Nam Dinh province, four compounds (1-4) were isolated by various chromatographic methods. These compounds were identified as haemanthamine (1), lycorine (2), 3-epimacronine (3) and 6-O-methylpretazettine (4) by spectroscopic methods including IR, MS, and NMR. These compounds were isolated from Euphorbia thymifolia Burm. for the first time. Compounds 1 and 2 showed potential cytotoxic activity against epithelial cancer cells (KB) with IC₅₀ values of 4.22 and 3.97 μM, respectively, and liver cancer cell lines (Hep G2) with IC₅₀values of 3.65 and 3.41 μM, respectively.