Journal of Medicinal Materials, 2017, Vol. 22, No. 3 (pp. 172-178)
CYTOTOXIC EFFECT OF ALKALOIDS FROM
EUPHORBIA THYMIFOLIA BURM. GROWN IN VIETNAM
Nguyen Tien Vung 1,*, Vu Duc Loi 2 , Bui Thanh Tung 2, Pham Giang Nam2
1National Institute of Forensic Medicine, Hanoi, Vietnam
2School of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam
*Corresponding author: email@example.com
(Received March, 16th, 2017)
Cytotoxic Effect of Alkaloids from Euphorbia thymifolia Burm. Grown in Vietnam
From 96% ethanol extract of Euphorbia thymifolia Burm. collected in Nam Dinh province, four compounds (1-4) were isolated by various chromatographic methods. These compounds were identified as haemanthamine (1), lycorine (2), 3-epimacronine (3) and 6-O-methylpretazettine (4) by spectroscopic methods including IR, MS, and NMR. These compounds were isolated from Euphorbia thymifolia Burm. for the first time. Compounds 1 and 2 showed potential cytotoxic activity against epithelial cancer cells (KB) with IC50 values of 4.22 and 3.97 μM, respectively, and liver cancer cell lines (Hep G2) with IC50 values of 3.65 and 3.41 μM, respectively.
Keywords: Euphorbia thymifolia Burm., Euphorbiaceae, Cytotoxicity, Haemanthamine, Lycorine.
(Nguồn tin: Tạp chí Dược liệu - Viện Dược liệu)