Journal of Medicinal Materials, 2017, Vol. 22, No. 3 (pp. 155-162)
THE EFFECTS OF CULTIVATED VIETNAMESE GINSENG EXTRACT
ON TRIMETHYLTIN-INDUCED NEURONAL LOSS
IN THE MOUSE DENTATE GYRUS
Nguyen Thi Thu Huong1,*, Pham Thi Nguyet Hang1, Taro Yamaguchi2,
Masanori Yoneyama2, Kyokazu Ogita2
1National Institute of Medicinal Materials, Research Center of Ginseng and Medicinal Materials,
Ho Chi Minh City, Vietnam;
2Department of Pharmacology, Setsunan University, Osaka, Japan
*Corresponding author: huongsam@hotmail.com
(Received April, 11th, 2017)
Summary
The Effects of Cultivated Vietnamese Ginseng Extract on Trimethyltin-Induced Neuronal Loss
in the Mouse Dentate Gyrus
The study evaluated the effect of cultivated Vietnamese ginseng extract (VGE) on neuronal repair following hippocampal neuronal damage by using a mouse model of trimethyltin (TMT)-induced neuronal loss/self-repair in the hippocampal dentate gyrus. The immunohistochemical examination and behavioral test (passive avoidance test) were applied. The results revealed that 15-day oral treatment with VGE (200 mg/kg) induced a significant increase in the number of BrdU-positive cells in the dentate three subregions, the GCL/SGZ, molecular layer, and hilus in TMT-treated mice, indicating that VGE is effective in promoting the recovery of granule neurons in TMT-induced neuronal loss. Interestingly, either 15-day or 30-day oral treatment with VGE induced an increase in the number of BrdU-positive cells in the dentate GCL/SGZ in naïve mice, suggesting that VGE is capable of enhancing neurogenesis in the brain. The results also showed that VGE treatment ameliorated the TMT-induced neurodegenerative symptoms observed in passive avoidance test, suggesting that VGE is capable of enhancing functional neuronal repair after neuronal loss in the dentate gyrus.
Keywords: Panax vietnamensis Ha et Grushv., Cultivated Vietnamese ginseng, Trimethyltin, Hippocampal dentate gyrus, Passive avoidance test.
(Nguồn tin: Tạp chí Dược liệu - Viện Dược liệu)