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Lignan and Flavonoids from Aerial Parts of Agrimonia pilosa Ledeb.

Journal of Medicinal Materials, 2017, Vol. 22, No. 3 (pp.146-151)

LIGNAN AND FLAVONOIDS FROM AERIAL PARTS

OF AGRIMONIA PILOSA LEDEB.

Nguyen Van Linh¹, Duong Thi Hai Yen², Hoang Le Tuan Anh^2,*, Vu Manh Hung³,

Nguyen Thi Mai⁴, Pham Thanh Ky^5,*

¹Military Institute of Traditional Medicine, Hanoi, Vietnam;

²Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST);

³Vietnam Military Medical University, Ha Dong, Hanoi, Vietnam;

⁴University of Transport and Communications, Hanoi, Vietnam;

⁵National Institute of Medicinal Materials, Hanoi, Vietnam

*Corresponding author: anh_792002@yahoo.com

(Received April 2017)

Summary

Lignan and Flavonoids from Aerial Parts of Agrimonia pilosa Ledeb.

By chromatographic separation, a lignan glycoside, (+) isolariciresinol-3a-O-b-D-glucopyranoside (1), and three known flavonoids, naringenin 7-O-β-D-glucopyranoside (2), leucoside (3) and kaempferol (4) were isolated from the methanol extract of the aerial parts of Agrimonia pilosa. Their structures were determined by 1D-, 2D-NMR spectroscopic analyses and in comparison with the reported data. Compound 2 exhibited weak anti-inflammatory effect toward inhibition of NO production with IC₅₀ value of 91.07 µg/ml. To our best knowledge, compounds 1 - 3 were isolated from genus Agrimonia for the first time.