\n\t\tSummary
\n\t\tLiver cirrhosis is often consequence of chronic alcohol abuse, but may be also the result of previous infection with hepatitis B, C, D. As liver cirrhosis is an intractable disease, the treatment of cirrhosis is aimed at stopping or delaying its progression,minimizing the damage to liver cells, and reducing complications. Treatment for hepatitis-related cirrhosis involves medications used to treat the different types of hepatitis,such as interferon, lamivudine etc..., and their combination with the herbal remedies. The last ones have been proved to have interesting properties such as decreasing serum transaminase (GPT, GOT) activity and bilirubin content, slowing and inhibiting of the progression of liver disease; low toxicity and low cost. Thus research on new herbal anti-hepatitis drugs is encouraged [1, 2, 6, 7].
\n\t\tHypericum patulum Thunb. ex Murray (HP) is growing wild in Vietnam. Quercitrin and Astilbin have been firstly proved as the major flavonoids in HP leaves [8].
\n\t\tAqueous and ethanolic extracts of HP have exhibited hepatoprotective effect on acute hepatitis in vivo test; anti-oxidant and anti-chronic inflammatory activities and inhibitory effect on the progression of chronic hepatitis and cirrhosis caused by injection of CCl4 for prolonged period in mice. Aqueous extract of HP decreased significantly by 26.4% the increase in content of hepatic collagen (P < 0.05) and by 22.6% of MDA content, alleviated histologically the cirrhosis and necrosis of liver cells.
\n\t\tIn addition, HP aqueous extract exhibited also choleretic effect, increasing by 78.6% the bile flow in comparison with control group.
\n\t\tQuercitrin isolated from HP showed hepatoprotective effect agianst acute hepatitis caused by short term injection of CCl4 in mice. Oral administration of 0.02g of quercitrin/kg of body weight reduced significantly by 59.67% the increase in activity of serum transaminase (GPT) and by 54.20% bilirubin content induced by CCl4 in comparison with that in untreated mice.
\n\t\tKey-words: Hypericum patulum Thunb. ex Murray; hepatoprotective effect; Anti-hepatitis.
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