Summary

Peroxydase Activity and Sulfhydryl Group Content in Liver of Mice Exposed

to Dichlorodiethyl Sulfide by Percutaneous Route and Effects of

Sodium Thiosulfate and Naturenz

Peroxydase and free sulfhydryl group (-SH) levels in mouse livers were determined at days 1^st, 7^th, 15^th and 30^th after mice was empoisoned by dichlorodiethyl sulfide (HD) with single dose of 1LD₅₀ by percutaneous route. Our results showed that, at the days 7^th, 15^th and 30^th after acute intoxication, peroxydase activity and -SH group concent in murine livers were significantly lower than those of the control group (p < 0,05); they were lowest at the day 7^th (redution 32.2% and 39.5% compared to control, respectively). Treatment with sodium thiosulfate alone increased considerably the -SH content but only at the days 7^th and 15^th while with Naturenz combined for 30 days (120 mg/kg daily), all disorders in peroxydase activity and -SH levels were completely resolved throughout the period of investigation.

Key words: dichlorodiethyl sulfide, peroxydase, sulfhydryl group, Naturenz.

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