Summary
Flavonoid Glycosides as Inhibitors of a-Amylase Isolated from the Leaves of Polyscias fruticosa
A phytochemical fractionation of the methanol extract of the leaves of Polyscias fruticosa (L.) Harms. led to the isolation of three flavonoid glycosides. By means of the spectroscopic methods including ESI-MS and 1D-NMR, the isolated compounds were determined to be quercitrin (1), afzelin (2) and kaempferol-3-O-rutinoside (3). Compounds 1 and 3 showed stronga-amylase inhibitory activity with the IC50 values of 4.61 and 59.4 mg/ml, respectively.
Keywords: Polyscias fruticosa, Araliaceae, flavonoid glycoside, a-amylase inhibitor.
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