Summary

In vitro Antioxidant and In vivo Prophylactic Effects of Extracts from Allium schoenoprasum L.against Hepatotoxicity in Carbon Tetrachloride Intoxicated Mice

Ethanolic (from 30 % to 90 %) extracts of chives Allium schoenoprasum L. were examined for free radical scavenging capacities and antioxidant activities. The antioxidant potency were investigated by employing various established in vitro systems, such as DPPH, β-carotene bleaching, the extracts showed significant free radical scavenging activity. The treatment with ethanolic extracts at oral doses of 250 and 500 mg/kg 14 days before CCl₄ administration (0.2 % of CCl₄ in olive oil, 10 ml/kg i.p.) significantly reduced the elevated plasma levels of aminotransferases. Extracts administration was also found to inhibit the toxicity produced by CCl₄ administration as seen from the decreased lipid peroxides (LPO) and increased glutathione (GSH) levels. The results revealed that the hepatoprotective activity of ethanolic extracts is significant as similar to the standard drug silymarin. These results suggest that the extracts could protect the hepatocytes from CCl₄- induced liver damage perhaps, by their anti-oxidative effect on hepatocytes, hence eliminating the deleterious effects of toxic metabolites from CCl₄.

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