Summary

Analgesic, Anti-imflammatory Activity of Stephamia dielsiana Y.C.Wu

Was Grown in Bavi District - Hanoi

In taxonomy, Stephania is a large genus which includes Stephania glabra (Roxb.) Miers.; Stephania kuinanennis H.S.Lo et M.Yang.; Stephania pierrei Diels. In our investigation we had studied this genus  and found one new species Stephania dielsiana Y.C.Wu. were grown in Bavi district, Hanoi. Base on relief pattern of Koster and Turner, we found that rats were obviously relieved pain by extract of the species at the dose 2.5g/kg and 5 g/kg body weight. Based on the model of pain by acetic acid, the extract in dose of 2.5g/kg and 5.0g/kg of body weight exhibited the analgesic effect, but not on the model of hot plate. In dose 2.5g/kg and 5 g/kg body weight on rats, the extract had provoked acute anti-inflammatory effect through inhibiting carrageenin induced edema in hind paw. Stephania dielsiana Y.C.Wu in dose 5 g/kg body weight on mice had a chronic anti-inflammatory effect. Anti-inflammatory effect is equivalent to prednisolon 5 mg/kg body weight on mice.

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