Journal of Medicinal Materials, 2017, Vol. 22, No. 3 (pp. 178-182)
STUDY ON THE SEDATIVE EFFECTS OF
“DUONG TAM AN THAN” CAPSULE
Pham Thi Nguyet Hang*, Phi Thi Xuyen
National Institute of Medicinal Materials, Hanoi, Vietnam
*Corresponding author: pnhang2004@yahoo.com
(Received April, 05th, 2017)
Summary
Study on the Sedative Effects of “Duong Tam An Than” Capsule
The objective of this study was to investigate the acute oral toxicity and the sedative effects of the “Duong Tam An Than” (DTAT) capsule through thiopental-induced sleeping time and spontaneous locomotor activity test in mice. The oral dose of DTAT selected in the trial was equivalent to 3 capsules and 6 capsules/kg of body weight. The results of acute oral toxicity test showed that LD50 was not able to be determined by oral administration, because a maximum oral dose equivalent to 77.2 capsules/kg of body weight was used, no mouse was dead. Pharmacological studies showed that DTAT in dose of 6 capsules/kg orally administered for 7 consecutive days exhibited the sedative effect by prolonging the sleeping time in thiopenthal-induced sleeping test and by decreasing spontaneous locomotor activity.
Keywords: “Duong Tam An Than” capsules, Sedative effect, Thiopental-induced sleeping test, Spontaneous locomotor activity.
(Nguồn tin: Tạp chí Dược liệu - Viện Dược liệu)