AN ANTI-INFLAMMATORY PYRROLE OLIGOGLYCOSIDE FROM THE STARFISH ASTERINA BATHERI LIVING IN VIETNAMESE SEA

Tran Thi Hong Hanh¹, Ninh Thi Ngoc¹, Le Duc Dat¹, Phan Thi Thanh Huong¹,

Nguyen Phuong Thao¹, Nguyen Tien Dat¹, Do Thi Thao²,  Nguyen Xuan Cuong^1,*,

Nguyen Hoai Nam¹, Do Cong Thung³, Phan Van Kiem¹, Chau Van Minh¹

¹Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)

²Institute of Biotechnology, Vietnam Academy of Science and Technology

³Institute of Marine Resources and Environment, VAST

*Corresponding author: cuongnx@hotmail.com

(Received June 9^th, 2014)

Summary

An Anti-Inflammatory Pyrrole Oligoglycoside from the Starfish Asterina batheri Living in Vietnamese Sea

A pyrrole oligoglycoside, 3-[O-b-D-fucopyranosyl-(1®3)-b-D-fucopyranosyl-(1®4)-{b-D-quinovopyranosyl-(1®2)}-b-D-quinovopyranosyl]-2-acetyl-pyrrole (1), was isolated from the methanol extract of the starfish A. batheri. Its structure was elucidated by 1D and 2D-NMR spectra. Compound 1 exhibited anti-inflammatory activity in mice using ethyl phenylpropiolate (EPP)-induced ear edema assay with ED₅₀ of 0.58 mg/ear.

Keywords: Starfish, Asterina batheri, Asterinidae, Pyrrole oligoglycoside, Anti-inflammatory activity.

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