Study on the Effects of Polysaccharide from Ganoderma lucidum and Ganoderma colossum on Microscopic Structures of Liver, Spleen and Thymus of Immunosuppressive Mice

Crude polysaccharides (PSP) were extracted from Ganoderma lucidum and Ganoderma colossum. Cyclophosphamide (150 mg/kg, intraperitoneal injection) was used to induce immunosuppressive model in mice. Hematoxylin-Eosin staining technique was applied for histological observation. The results revealed that structural damages were identified in liver, spleen and thymus of cyclophosphamide-immunosuppressed mice. Either PSP from Ganoderma lucidum or PSP from Ganoderma colossum had no hepatoprotective effect on liver damage. The PSP from Ganoderma lucidum and Ganoderma colossum had proliferating effects on thymus central medulla and spleen pulp in cyclophosphamide-immunosuppressed mice. Our results support the enhancing effect of Ganoderma lucidum or Ganoderma colossum on immunological function in individuals undergoing chemotherapy for cancer or other immunosuppressive therapies.

Keywords: Ganoderma lucidum, Ganoderma colossum, polysaccharide, cyclophosphamide, hematoxylin-eosin staining, microscopic observation

(Nguồn tin: )