Summary

Study on Influences of the Combined Antimalarial Drug Piperaquine plus Dihydroartemisinin in Rabbit Isolated Heart

The present study was conducted at the Department of Pharmacology and Biochemistry, Institute of Medicinal Materials, between June and July, 2007. The influences of the combined antimalarial drug (320 mg piperaquine phosphate (PQP) and 40 mg dihydroartemisinin (DHA), made with the materials produced by Institute of chemistry) in rabbit isolated heart were investigated at two different concentrations. The results showed that:

At the concentration 0.001% of PQP - DHA  (0.89 mg of PQP and 0.11 mg of DHA / 100 mL, infused consecutively for 25 minutes), the combination of PQP - DHA did not affect significantly rabbit heart rhythm, decreased slightly cardiac output and rather  increased cardiac contractile force. But these changes were not statistically significant.

At the concentration 0.002% of PQP - DHA (1.78 mg of PQP and 0.22 mg of DHA / 100 mL, infused consecutively for 25 minutes), the combination decreased considerably rabbit heart rhythm and contractile force, and also reduced cardiac output.

PQP - DHA affected significantly rabbit heart rhythm, cardiac output and contractile force at the concentration 0.002% of PQP - DHA, infused  consecutively for 25 minutes.

Key words: Piperaquin, dihydroartemisinin, combined antimalarial drug, rabbit  isolated heart. 

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