Summary

Study on Antioxidant Effects of Phellinus linteus (Hymenochaetaceae)

Phellinus linteus (Berkeley & M. A. Curtis) is a medicinal mushroom that has been practiced in oriental countries for centuries to prevent ailments as diverse as gastroenteric dysfunction, diarrhea, haemorrhage and cancers. Recently, research has been focused on the anti-tumor effect, and in particular, on its ability to enhance some conventional chemotherapeutic drugs. Polysaccharide isolated from Phellinus linteus inhibits tumor growth and metastasis by enhancing immune functions of macrophages, dendritic cells, NK cells, T cells, and B cells. Phellinus linteus extract had a cellular defensive effect against DNA damage induced by reactive oxygen species.

The purpose of this study was to evaluate the in vitro antioxidant activity and hepatoprotective effect of ethanol extract and aqueous extract of Phellinus linteus on liver injury induced by cyclophosphamide in mice. The free radical scavenging effect on the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH test) and the anti-lipid peroxidation effect (malonyl dialdehyde test) of these extracts were the highest at 1000-2000mg/ml. Both ethanol extract and aqueous extract (at the doses equivalent to 5g raw material/kg body weight) produced the protective effects against cyclophosphamide-induced oxidative damage.

Key words: Phellinus linteus, antioxidant activity, cyclophosphamide, oxidative damage

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