Studies on Chemical Composition from the Leaves of Telosma cordata

The methanolic extract from the leaves of Telosma cordata showed in vitro cytotoxic activity against Hep-G2 (heptonema carcinoma), Fl (fibril sarcoma of uterus) and RD (rhabdosarcoma) with the ED values of 39.0%, 12.6% and 5.6%, respectively. Fractionation of the extracts gave compounds belonging to different classes. Four compounds: lutein (1), 1-dotriacontanol (2), 24E-stigmasta-5,22-dien-3b-ol (3), and daucosterol (4) were isolated from the n-hexane extracts. These structures were elucidated by analysis of the NMR data.

Keywords: Telosma cordata, cytotoxic activity, lutein, 1-dotriacontanol, stigmasterol, daucosterol.

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