Journal of Medicinal Materials, 2024, Vol. 29, No. 2 (pp. 92 - 98)

ACETYLCHOLINESTERASE INHIBITORY ACTIVITY

OF EMBELIA RIBES BURM. F. FRUITS COLLECTED

IN SOUTHERN VIETNAM AND ITS CHEMICAL COMPONENTS

Phan Thanh Thuy¹, Pham Thi Nguyet Hang¹, Nguyen Minh Khoi¹, Nguyen Van Tai¹,

 Tran Thi Tuyet², Nguyen Thi Ly¹, Phan Van Truong¹, Le Thanh Nghi^1,*

¹National Institute of Medicinal Materials, Hanoi, Vietnam;

²Dai Nam University, Hanoi, Vietnam

*Corresponding authors: thanhnghi.vdl@gmail.com

(Received October 08^th, 2023)

Summary

Acetylcholinesterase Inhibitory Activity of Embelia ribes Burm. f. Fruits Collected in Southern Vietnam

and its Chemical Components

Extracts from Embelia ribes Burm. f. fruits in southern Vietnam showed good effects on acetylcholinesterase (AChE) inhibition, with IC₅₀ values of 0.23-0.45 mg/ml. Among them, the dichloromethane fraction showed the potent inhibitory activity. The chemical investigation of this fraction resulted in the isolation of five compounds (1-5). Their chemical structures were identified as kaempferol (1), quercetin (2), hydroxymethylfurfural (3), 5-(8′-Z-heptadecenyl)resorcinol (4), and embelin (5) based on spectral data analysis and literature references. The in vitro AChE inhibitory activity shows embelin may be a principal compound in the most active dichloromethane fraction.

Keywords: Embelia ribes, Acetylcholinesterase, Embelin.

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