Journal of Medicinal Materials, 2021, Vol. 26, No. 3 (pp. 149 - 154)
ALKALOIDS AND FLAVONOIDS FROM LYCOPODIELLA CERNUA
Vu Huong Giang1, Le Thi Thuy2, Pham Thi Cham1, Le Ba Vinh1,*, Ninh Khac Ban1,
Tran My Linh1, Nguyen Chi Mai1, Pham Thi Hoe1, Tran Thu Huong2, Nguyen Hai Dang3,
Tran Hong Quang1,*
1Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Vietnam;
2School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, Vietnam;
3University of Science and Technology of Hanoi, VAST, Hanoi, Vietnam
*Corresponding author: quangtranhong@imbc.vast.vn or lebavinh.imbc@gmail.com
(Received April 27th, 2021)
Summary
Alkaloids and Flavonoids from Lycopodiella cernua
Using combined various chromatography separation methods, six compounds (1 - 6) were isolated from the whole plants of Lycopodiella cernua, including three alkaloids cernuine (1), lycocernuine (2), cermizine C N-oxide (3) and three flavonoid glycosides apigenin-4'-O-(2''-O-p-coumaroyl)-β-D-glucopyranoside (4), apigenin-4'-O-(6''-O-p-trans-coumaroyl)-β-D-glucopyranoside (5), and apigenin-4'-O-(2'',6''-di-O-trans-p-coumaroyl)-β-D-glucopyranoside (6). Their structures were elucidated using 1D and 2D-NMR experiments and comparison with those reported in the literature. All the compounds showed weak inhibitory effects on NO production in LPS-stimulated BV2 microglial cells, with IC50 values ranging from 30.1 ± 1.5 to 68.6 ± 3.4 µM. Compound 5 also showed weak cytotoxic activity against three human cancer cell lines: MCF-7 (breast carcinoma), HepG2 (hepatocarcinoma), and SK-Mel2 (melanoma).
Keywords: Lycopodiella cernua, Alkaloid, Cernuin, Flavonoid glycoside, Apigenin glycoside.
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