Journal of Medicinal Materials, 2020, Vol. 25, No. 5 (pp. 303 - 307)
ANTI-HYPERTENSIVE EFFECTS OF FLAVONOID-ENRICHED EXTRACT FROM DIOSPYROS KAKI L.f. LEAVES
ON RENO-VASCULAR HYPERTENSIVE RATS
Nguyen Thị Thanh Loan1,2, Le Thi Xoan1,*, Pham Thi Nguyet Hang1, Nguyen Van Tai1,
Nguyen Thi Bich Thu3
1National Institute of Medicinal Materials, Vietnam;
2Department of Pharmacology, Hanoi Medical University, Vietnam;
3Faculty of Pharmacy, Duy Tan University, Danang, Vietnam
*Corresponding author: firstname.lastname@example.org
(Received September, 15th, 2020)
Anti-Hypertensive Effects of Flavonoid-Enriched Extract from Diospyros kaki L.f. Leaves
on Reno-Vascular Hypertensive Rats
Current study designed to investigate the anti-hypertensive effect of flavonoid-enriched extract from Diospyros kaki L.f. leaves (DKF) on renovascular hypertensive rats. The Wistar rats were induced hypertension by narrowing the left renal artery using 2 kidney-1 clip experimental model of renovascular hypertension (2K1C). The reno-hypertensive rats were daily treated with DKF (50 and 100 mg/kg of body weight; p.o.) or captopril (20 mg/kg of body weight; p.o.), a reference drug for 4 weeks. The blood pressure and heart rate were performed to assess the anti-hypertensive effect of DKF for every 2 weeks. The daily administration of DKF dose-dependently reduced the systolic and diastolic blood pressures in renovascular hypertensive rats. There were no significant changes observed in heart rate. Our results demonstrated that DKF exhibits anti-hypertensive effects on reno-hypertensive rat and that the DKF treatment may be an useful herbal therapy for the management of hypertension.
Keywords: Diospyros kaki L.f. leaves, Anti-hypertensive effect, Two-kidney one-clip model.
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