Journal of Medicinal Materials, 2020, Vol. 25, No. 3 (pp. 171 - 175)

ANTI-HYPERTENSIVE EFFECTS OF LEEA RUBRA EXTRACT

ON RENO-VASCULAR HYPERTENSIVE RATS

Le Thi Xoan^1,*, Tran Trong Trieu^1,2, Nguyen Thi Phuong¹, Tran Nguyen Hong¹,

Pham Thi Nguyet Hang¹, Nguyen Van Tai³, Nguyen Thi Phuong⁴

¹Department of Pharmacology and Biochemistry, National Institute of Medicinal Materials, Hanoi, Vietnam;

²Hanoi University of Pharmacy, Vietnam;

³Department of Phytochemistry, National Institute of Medicinal Materials, Hanoi, Vietnam;

⁴Department of Analytical Chemistry and Standardization, National Institute of Medicinal Materials, Hanoi, Vietnam

*Corresponding author: xoanle@nimm.org.vn

(Received May 18^th, 2020)

Summary

Anti-Hypertensive Effects of Leea rubra Extract on Reno-Vascular Hypertensive Rats

This study was conducted to evaluate the anti-hypertensive effect of Leea rubra (LR) extract on reno-vascular hypertensive rats. The Wistar rats were induced hypertensive by narrowing the left renal artery using 2 kidney-1 clip experimental model of renovascular hypertension (2K1C). The hypertensive rats were treated with LR aqueous extract at the daily dose of 100 and 300 mg/kg of body weight. The blood pressure and heart rate of rats were determined at 0, 2 and 4 weeks after the drug administration. The daily administration of LR extract at doses of 300 mg/kg for 2 - 4 weeks reduced the systolic and diastolic blood pressures in renovascular hypertensive rats without affecting the heart rate. Our results demonstrated that LR aqueous extract exhibits anti-hypertensive effects in the 2K1C rat model of renovascular hypertension. Thus, LR aqueous extract may be beneficial for the treatment of hypertension.

Keywords: Leea rubra, Antihypertensive, Angiotensin 1-converting Enzyme, 2K1C model.

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