Journal of Medicinal Materials, 2021, Vol. 26, No. 5 (pp. 307 - 311)
ANTI-OSTEOCLASTOGENIC PLANTS
FROM THE NORTHERN PART OF VIETNAM
Le Thanh Huong1, Le Hoang Long1, Nguyen Tien Dat2, Tran Phuong Thao3, Jeong-Hyung Lee3, Nguyen Hai Dang1,*
1University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam;
2Center for Research and Technology Transfer, VAST, Hanoi, Vietnam;
3Department of Biochemistry, Kangwon National University, Chuncheon, Gangwon-Do 24341, Korea
*Corresponding author: nguyen-hai.dang@usth.edu.vn
(Received September 13th, 2021)
Summary
Anti-Osteoclastogenic Plants from the Northern Part of Vietnam
The skeletal system is a highly dynamic environment in which osteoclasts and osteoblasts coexist. However, when osteoclasts become overactive, they can lead to bone illnesses like osteoporosis. Scientists have well understood that the mechanism by which osteoclasts are stimulated is RANKL/RANK. As a result, various drugs have been developed to suppress this pathway; nonetheless, side effects have caused consumers to be concerned. To overcome this problem, they approached plant-based drugs. In this paper, anti-osteoclastogenesis properties of 23 botanical species were screened. After being treated on RANKL-induced osteoclasts, nine samples exhibited strongly anti-osteoclastogenesis effects. Three samples: Cyperus stoloniferus (S13); Desmodium styracifolium (S17); and Symplocos sumuntia (S22) were first reported on their anti-osteoclastogenetic activity.
Keywords: Plant extract, Osteoclastogenesis, Osteoclast differentiation, Osteoporosis, Bone resorption.
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