Journal of Medicinal Materials, 2018, Vol. 23, No. 3 (pp. 179 - 184)
ANTIOXIDANT AND CYTOTOXIC ACTIVITY OF CINNAMTANIN B1 –
AN OVEREXPRESSED COMPOUND OF PTERIS VITTATA L.
UNDER HEAVY METAL STRESS
Nguyen Ngoc Lien1, Do Hoang Giang2, Bui Thi Mai Anh2, Do Cong Viet1, Nguyen Van Tai3, Pham Hoang Nam1, Marie-Geneviève Dijoux-Franca5, Nguyen Tien Dat4, Nguyen Thi Kieu Oanh1, *
1University of Science and Technology of Hanoi (USTH), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam, Hanoi, Vietnam
3Institute of Natural Product Chemistry (INPC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam
4Center for Research and Technology Transfer (CRETECH), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam
5UMR 5557 Ecologie Microbienne, CNRS, INRA, VetagroSup, UCBL, Université de Lyon, 43 Boulevard du 11 Novembre, F-69622 Villeurbanne, France
*Corresponding author: email@example.com
(Received May, 10th, 2018)
Antioxidant and Cytotoxic Activity of Cinnamtanin B1 - an Overexpressed Compound of Pteris vittata L.
Under Heavy Metal Stress
Cinnamtannin B1 is a naturally occuring A-type proanthocyanidin comprised of three monomeric units of flavan-3-ol ((−) epicatechin) (epicatechin-(4β→8,2β→O→7)-epicatechin-(4α→8)-epicatechin) that was for the first time isolated from the roots of Pteris vittata L. growing in Thai Nguyen province. The UHPLC - DAD analysis showed that cinnamtannin B1 is one of overexpressed compounds in this hyperaccumulator under heavy metal stress. This compound was evaluated for its antioxidant on DPPH scavenging capacity and cytotoxic activity against human pancreatic carcinoma (PANC-1) cell line with the IC50 value of 75.7 µM and 62.3 µM, respectively.
Keywords: Cinnamtannin B1, Pteris vittata, DPPH, PANC-1.
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