Journal of Medicinal Materials, 2018, Vol. 23, No. 3 (pp. 179 - 184)

ANTIOXIDANT AND CYTOTOXIC ACTIVITY OF CINNAMTANIN B1 –

AN OVEREXPRESSED COMPOUND OF PTERIS VITTATA L.

UNDER HEAVY METAL STRESS

Nguyen Ngoc Lien¹, Do Hoang Giang², Bui Thi Mai Anh², Do Cong Viet¹, Nguyen Van Tai³, Pham Hoang Nam¹, Marie-Geneviève Dijoux-Franca⁵, Nguyen Tien Dat⁴, Nguyen Thi Kieu Oanh^1, *

¹University of Science and Technology of Hanoi (USTH), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam, Hanoi, Vietnam

³Institute of Natural Product Chemistry (INPC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam

⁴Center for Research and Technology Transfer (CRETECH), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam

⁵UMR 5557 Ecologie Microbienne, CNRS, INRA, VetagroSup, UCBL, Université de Lyon, 43 Boulevard du 11 Novembre, F-69622 Villeurbanne, France

*Corresponding author: nguyen-thi-kieu.oanh@usth.edu.vn

(Received May, 10^th, 2018)

Summary

Antioxidant and Cytotoxic Activity of Cinnamtanin B1 - an Overexpressed Compound of Pteris vittata L.

Under Heavy Metal Stress

Cinnamtannin B1 is a naturally occuring A-type proanthocyanidin comprised of three monomeric units of flavan-3-ol ((−) epicatechin) (epicatechin-(4β→8,2β→O→7)-epicatechin-(4α→8)-epicatechin) that was for the first time isolated from the roots of Pteris vittata L. growing in Thai Nguyen province. The UHPLC - DAD analysis showed that cinnamtannin B1 is one of overexpressed compounds in this hyperaccumulator under heavy metal stress. This compound was evaluated for its antioxidant on DPPH scavenging capacity and cytotoxic activity against human pancreatic carcinoma (PANC-1) cell line with the IC₅₀ value of 75.7 µM and 62.3 µM, respectively.

Keywords: Cinnamtannin B1, Pteris vittata, DPPH, PANC-1.

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