Journal of Medicinal Materials, 2021, Vol. 26, No. 1+2 (pp. 15 - 19)

CHEMICAL CONSTITUENTS FROM CHINESE ARTICHOKE RHIZOME (STACHYS AFFINIS BUNGE) AND THEIR ANTI-MICROBIAL ACTIVITIES

Nguyen Thanh Hoang¹, Vo Van Leo¹, Nguyen Viet Kinh¹, Vo Thi Bach Hue¹, Pham Quang Binh², Nguyen Thi Vy Phuong², Ma Chi Thanh^1,*

¹Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City;

²Tipharco Pharmaceutical Joint Stock Company

*Corresponding author: mcthanh@ump.edu.vn

(Received November 05^th, 2020)

Summary

Chemical Constituents from Chinese Artichoke Rhizome (Stachys affinis Bunge)

and their Anti-Microbial Activities

Chinese artichoke (Stachys affinis Bunge, Lamiaceae) has long been cultivated and used as an edible medicinal plant in China, Japan, and several countries in Europe. Four compounds were isolated and identified as stachyose, ethyl a-galactopyranoside, 8-O-acetyl-harpagide, and harpagide. The isolation and structure determination of compounds were used based on the chromatographic techniques and the spectroscopic methods (MS, 1D and 2D NMR). Stachyose and ethyl a-galactopyranoside showed significant inhibitory effects against Streptococcus pyogenes with MIC values of 8 and 4 mg/mL, respectively.

Keywords: Stachys affinis, Stachyose, 8-O-acetyl-harpagide harpagide, Anti-microbial activity.

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