Journal of Medicinal Materials, 2021, Vol. 26, No. 1+2 (pp. 15 - 19)
CHEMICAL CONSTITUENTS FROM CHINESE ARTICHOKE RHIZOME (STACHYS AFFINIS BUNGE) AND THEIR ANTI-MICROBIAL ACTIVITIES
Nguyen Thanh Hoang1, Vo Van Leo1, Nguyen Viet Kinh1, Vo Thi Bach Hue1, Pham Quang Binh2, Nguyen Thi Vy Phuong2, Ma Chi Thanh1,*
1Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City;
2Tipharco Pharmaceutical Joint Stock Company
*Corresponding author: firstname.lastname@example.org
(Received November 05th, 2020)
Chemical Constituents from Chinese Artichoke Rhizome (Stachys affinis Bunge)
and their Anti-Microbial Activities
Chinese artichoke (Stachys affinis Bunge, Lamiaceae) has long been cultivated and used as an edible medicinal plant in China, Japan, and several countries in Europe. Four compounds were isolated and identified as stachyose, ethyl a-galactopyranoside, 8-O-acetyl-harpagide, and harpagide. The isolation and structure determination of compounds were used based on the chromatographic techniques and the spectroscopic methods (MS, 1D and 2D NMR). Stachyose and ethyl a-galactopyranoside showed significant inhibitory effects against Streptococcus pyogenes with MIC values of 8 and 4 mg/mL, respectively.
Keywords: Stachys affinis, Stachyose, 8-O-acetyl-harpagide harpagide, Anti-microbial activity.
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