Journal of Medicinal Materials, 2022, Vol. 27, No. 6 (pp. 323 - 330)
CHEMICAL CONSTITUENTS FROM A MARINE-DERIVED ACTINOMYCETE MICROMONOSPORA AURANTIACA G657
Phi Thi Dao1, Nguyen Thuy Linh1, Le Thi Hong Minh1, Vu Thi Quyen1,
Doan Thi Mai Huong1,2,*, Pham Van Cuong 1,2,*
1Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST),
Hanoi, Vietnam;
2Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam
*Corresponding author: huongdm@imbc.vast.vn or phamvc@imbc.vast.vn
(Received August 16th, 2022)
Summary
Chemical Constituents from a Marine-Derived Actinomycete Micromonospora aurantiaca G657
Seven compounds astellolide A (1), cyclopiazonic acid (2), cyclopiamide F (3), 5,6-epoxyergosterol (4), 3-indolecarbadehyde (5), 2'-deoxythymidine (6) and uridine (7) were isolated and characterized from the culture broth of the marine-derived Micromonospora aurantiaca G657 strain, which was isolated from the sponge sample collected at Van Phong, Khanh Hoa, Vietnam. Their structures were determined by analyses of mass spectroscopy (MS), nuclear magnetic resonance spectroscopy (NMR) and comparison with the reference data. To the best of our knowledge, this is the first report of the isolation of astellolide A (1), cyclopiazonic acid (2), cyclopiamide F (3) from Micromonospora aurantiaca.
Keywords: Micromonospora aurantiaca, Indole-tetramic Acid alkaloid, Drimane-type sesquiterpene, Pyrimidine nucleoside.
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