Ấn phẩm

Chemical Constituents of the Endophytic Fungus Penicillium shearii Isolated from Pyrrosia lanceolata (L.) Farw. (Journal of Medicinal Materials, 2023, Vol. 28, No. 2)

Journal of Medicinal Materials, 2023, Vol. 28, No. 2 (pp. 83 - 89)

 

CHEMICAL CONSTITUENTS OF THE ENDOPHYTIC FUNGUS

PENICILLIUM SHEARII ISOLATED FROM PYRROSIA LANCEOLATA (L.) FARW.

Ma Chi Thanh1,*, Nguyen Thanh Dan1, Ho Le Truc Linh1, Ly Tu Loan2

1Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam;

2Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam

*Corresponding author: mcthanh@ump.edu.vn

(Received March 09th, 2023)

Summary

Chemical Constituents of the Endophytic Fungus Penicillium shearii Isolated from Pyrrosia lanceolata (L.) Farw.

Endophytic fungi are one of the typical endophytic microorganism groups that have been particularly interested in research recently because of their roles in many aspects; the most special thing is the ability to biosynthesize secondary substances with biological activity such as antioxidant, antibacterial, anti-tumor... The endophytic fungal strains were identified as Penicillium shearii CBS 290.48 by morphological microscopic and DNA sequencing based on the modified Sanger method. From the ethyl acetate fraction of the medium extract of P. shearii, four compounds were isolated and identified as ergosterol (1), dehydroxypaxilline (2), chrysophanol (3), and paspaline (4). Their structures were determined by means of spectroscopic methods (MS, 1D, and 2D NMR).

Keywords: Penicillium shearii, Endophytic fungus, Pyrrosia lanceolata, DNA sequencing.

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