Journal of Medicinal Materials, 2021, Vol. 26, No. 5 (pp. 263 - 267)
CHROMONE DERIVATIVES FROM AGARWOOD
OF AQUILARIA CRASSNA PIERRE EX LECOMTE
Vo Thi Kim Nien1, Tran Quoc Huy1, Duong Hong To Quyen2, Nguyen Phuong Nam2,
Ly Tu Loan3, Ma Chi Thanh1,*
1Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam;
2Hospital of Traditional Medicine in Ho Chi Minh City, Vietnam;
3Ton Duc Thang University, Ho Chi Minh City, Vietnam
*Corresponding author: email@example.com
(Received June 29th, 2021)
Chromone Derivatives from the Agarwood of Aquilaria crassna Pierre ex Lecomte
Agarwood (Aquilaria crassna Pierre ex Lecomte, Thymelaeaceae) has been used in traditional medicine for the treatment of insomnia, anxiety, asthma, cold, analgesic, and digestive disorder in Vietnam. Five compounds were isolated and identified as 6-hydroxy-2-(2-phenylethyl)chromone (1), 6-hydroxy-2-[2-(4'-methoxyphenyl)ethyl]chromone (2), 5-hydroxy-6-methoxy-2-[2-(4'-methoxyphenyl)ethyl]chromone (3), 5-hydroxy-7,3',4'-trimethoxy-flavone (4), and 6-methoxy-2-(2-phenylethyl)chromone (5) from the ethyl acetate fration of agarwood of A. crassna. Their structures were determined by the mean of spectroscopic methods (MS, 1D and 2D NMR). Compounds 2 - 5 were first reported from the agarwood of Aquilaria crassna.
Keywords: Aquilaria crassna, Thymelaeaceae, Agarwood, Chromone derivatives.
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