Journal of Medicinal Materials, 2021, Vol. 26, No. 5 (pp. 263 - 267)

CHROMONE DERIVATIVES FROM AGARWOOD

OF AQUILARIA CRASSNA PIERRE EX LECOMTE

Vo Thi Kim Nien¹, Tran Quoc Huy¹, Duong Hong To Quyen², Nguyen Phuong Nam²,

Ly Tu Loan³, Ma Chi Thanh^1,*

¹Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam;

²Hospital of Traditional Medicine in Ho Chi Minh City, Vietnam;

³Ton Duc Thang University, Ho Chi Minh City, Vietnam

*Corresponding author: mcthanh@ump.edu.vn

(Received June 29^th, 2021)

Summary

Chromone Derivatives from the Agarwood of Aquilaria crassna Pierre ex Lecomte

Agarwood (Aquilaria crassna Pierre ex Lecomte, Thymelaeaceae) has been used in traditional medicine for the treatment of insomnia, anxiety, asthma, cold, analgesic, and digestive disorder in Vietnam. Five compounds were isolated and identified as 6-hydroxy-2-(2-phenylethyl)chromone (1), 6-hydroxy-2-[2-(4'-methoxyphenyl)ethyl]chromone (2), 5-hydroxy-6-methoxy-2-[2-(4'-methoxyphenyl)ethyl]chromone (3), 5-hydroxy-7,3',4'-trimethoxy-flavone (4), and 6-methoxy-2-(2-phenylethyl)chromone (5) from the ethyl acetate fration of agarwood of A. crassna. Their structures were determined by the mean of spectroscopic methods (MS, 1D and 2D NMR). Compounds 2 - 5 were first reported from the agarwood of Aquilaria crassna.

Keywords: Aquilaria crassna, Thymelaeaceae, Agarwood, Chromone derivatives.

(Nguồn tin: )