Journal of Medicinal Materials, 2022, Vol. 27, No. 6 (pp. 343 - 350)
CYCLOPEPTIDES FROM THE MARINE ACTINOMYCETE DIETZIA SP. G727 DERIVED FROM THE SEAWEED LOBOPHORA SP.
Nguyen Thi Hue1, Do Thi Quynh1, Nguyen Mai Anh1, Le Thi Hong Minh1, Phi Thi Dao1,
Nguyen Thuy Linh1, Doan Thi Mai Huong1,2,*, Pham Van Cuong1,2,*
1Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST);
2Faculty of Chemistry, Graduate University of Science and Technology, VAST
*Corresponding author: email@example.com or firstname.lastname@example.org
(Received November 04th, 2022)
Cyclopeptides from the Marine Actinomycete Dietzia sp. G727
Derived from the Seaweed Lobophora sp.
From the methanol extract of the Dietzia sp. G727 derived from the seaweed Lobophora sp., seven compounds were isolated including staphylopeptide A (1), cyclo-(L-Pro-L-Asn) (2), cyclo-(L-Pro-L-Ser) (3), cyclo-(L-Pro-L-Thr) (4), cyclo-(L-Ala-4-hydroxy-L-Pro) (5), adenine (6) and adenosine (7). Their structures were elucidated by the nuclear magnetic resonance (NMR) spectroscopy, mass spectroscopy (MS) and comparison with the reference data. Compounds 3, 5 and 6 showed good antimicrobial activity against Enterococcus faecalis and Candida albicans with the MIC values in the range from 32 to 128 µg/mL. In addition, only compound 6 inhibited Gram-negative bacteria Escherichia coli with a MIC value of 64 µg/mL. To the best of our knowledge, this is the first report of the isolation of staphylopeptide A from Dietzia genus.
Keywords: Dietzia genus, Marine actinomycete, Cyclodipeptide, Cyclotetrapeptide, Antimicrobial activity.
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