Journal of Medicinal Materials, 2022, Vol. 27, No. 1 (pp. 31 - 37)

CYTOTOXIC AND ANTIMICROBIAL ACTIVITIES OF ESSENTIAL OILS FROM THE FRUITS OF ZANTHOXYLUM RHETSA GROWN

IN THANH HOA PROVINCE, VIETNAM

Pham Cao Bach¹, Tran Thi Tuyen¹, Dinh Thi Thu Thuy¹, Do Huu Nghi¹, Trinh Anh Vien³,

Cam Thi Inh¹, Nguyen Thi Hong Van^1,2,*
¹Institute of Natural Products Chemistry (INPC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam;

²Graduate University of Sciences and Technology (GUST), VAST, Hanoi, Vietnam;

3Hanoi Medical University, Vietnam

*Corresponding author: nguyenthihongvan.inpc.vast@gmail.com

(Received January 19^th, 2022)

Summary

Cytotoxic and Antimicrobial Activities of Essential Oils from the Fruits of Zanthoxylum rhetsa

Grown in Thanh Hoa Province, Vietnam

The essential oils from the fresh and dried fruits of Zanthoxylum rhetsa grown in Thanh Hoa province were obtained by hydrodistillation and analyzed by gas chromatography (GC-FID) and gas chromatography/mass spectrometry (GC/MS). The major constituents of fresh fruit essential oil (FF) and dried fruit essential oil (DF) were sabinene, limonene, β-phellandrene, and α-pinene, but their contents in two essential oils were not the same, these values ​​are 51.95%, 7.84%, 7.69%, 3.82% in FF and 32.88%, 20.95%, 9.20%, 4.22% in DF, respectively. In addition, α-phellandrene presents at high content in the DF (10.23%) but it is only the minor component in the FF (0.65%). The EOs were also tested for their cytotoxic and antimicrobial activities. The IC₅₀ values revealed that these two essential oils exhibited a moderate activity against two tested cancer cell lines (MCF-7 and HeLa). For the antimicrobial activities, the FF showed its inhibitory effect on E. coli and B. subtillis (MIC values of 100 µg/mL), while the DF exhibited its potential antimicrobial activity against E. coli, F. oxysporum (MIC values of 100 µg/mL) and weak activity against P. aeruginosa (MIC value of 200 µg/mL).

Keywords: Zanthoxylum rhetsa, Essential oil, Rutaceae, Thanh Hoa province, Vietnam.

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