Journal of Medicinal Materials, 2023, Vol. 28, No. 2 (pp. 67 - 72)

DITERPENES FROM THE STEM BARK

OF TAXUS WALLICHIANA ZUCC. AND THEIR CYTOTOXIC ACTIVITY

Ninh Thi Ngoc¹, Nguyen Viet Phong¹, Tran Hong Quang¹, Dang Viet Cuong¹, Tran Thi Hong Hanh¹, Nguyen Xuan Cuong¹, Chu Hoang Ha², Nguyen Hoai Nam^1,*

¹Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST);

²Institute of Biotechnology, VAST, Hanoi, Vietnam

*Corresponding author: namnguyenhoai@imbc.vast.vn

(Received December 12^th, 2022)

Summary

Diterpenes from the Stem Bark of Taxus wallichiana Zucc. and their Cytotoxic Activity

By various chromatographic methods, seven known diterpenes, including two tricyclic-diterpenes containing a tropone ring (1 and 2) and five 11(15→1)-abeo-taxane diterpenes (3−7), were isolated from the methanol extract of the stem bark of Taxus wallichiana Zucc. The chemical structures of the isolated compounds were confirmed by ESI−MS, 1D, and 2D NMR as well as by comparison with the literatures. All isolated compounds were tested in vitro for their cytotoxic activity against the HepG2, SK-LU-1, MCF-7, LNCaP, and SK-Mel-2 human cancer cell lines. Among them, compounds 1 and 2 showed cytotoxicity against all tested cancer cell lines, with IC₅₀ values ranging from 17.8 to 61.5 μM.

Keywords: Taxus wallichiana Zucc., Taxaceae, Diterpene, Cytotoxic activity.

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