Journal of Medicinal Materials, 2020, Vol. 25, No. 3 (pp. 165 - 170)

EVALUATION OF XANTHINE OXIDASE INHIBITORY ACTIVITY OF MORUS ALBA L. LEAVES: AN IN VITRO AND IN SILICO APPROACH

Nguyen Thu Hang,  Nguyen Van Phuong*_, Lai Thai Huy

Department of Pharmacognosy, Hanoi University of Pharmacy, Hanoi, Vietnam

*Corresponding author: phuongnv@hup.edu.vn

(Received March 19^th, 2020)

Summary

Evaluation of Xanthine Oxidase Inhibitory Activity of Morus alba L. Leaves: An in vitro and in silico Approach

The objective of this research was to evaluate the xanthine oxidase inhibitory activity in vitro of ethanol extracts and n-hexane, ethyl acetate, and water fractions from mulberry leaves (Morus alba  L.). The results showed that ethanol and n-hexane extracts of mulberry leaves exhibited intermediate XO inhibitory activity with an IC₅₀ value of 45.08 µg/ml and 44.81 µg/ml, respectively. On the other hand, the ethyl acetate extract demonstrated the strongest effect on XO inhibition with an IC₅₀ value of 5.34 µg/ml, while the water extract did not show any XO inhibitory activity with IC₅₀ value above 300 µg/ml. The molecular docking results revealed that aryl benzofurans and flavonoids might play an important role in the biological effect of this medicinal plant. Our findings suggested that mulberry leaves will be the potent resource of natural xanthine oxidase inhibitors.

Keywords: In vitro, Molecular docking, Morus alba, Mulberry leaf, Xanthine oxidase.

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