Ấn phẩm

Flavonoids from Knema squamulosa W.J. de Wild. and their Antimicrobial Activity (Journal of Medicinal Materials, 2022, Vol. 27, No. 2)

Journal of Medicinal Materials, 2022, Vol. 27, No. 2 (pp. 82 - 86)

 

Flavonoids FROM KNEMA SQUAMULOSA W.J. de Wild.

and THEIR antimicrobial activity

Nguyen Ngoc Tung1, Le Thi Tam1, Pham Thi Mai Huong2, Nguyen The Cuong3,

Nguyen Xuan Cuong2, Tran Hong Quang2, Tran Thi Hong Hanh2,*

1Center for Research and Technology Transfer, Vietnam Academy of Science and Technology, Hanoi Vietnam;

2Institute of Marine Biochemistry, VAST, Hanoi, Vietnam;

3Institute of Ecology and Biological Resources, VAST, Hanoi, Vietnam

*Corresponding author: honghanh.imbc@gmail.com

(Received March, 01st, 2022)

Summary

Flavonoids from Knema squamulosa W.J. de Wild. and their Antimicrobial Activity

Using chromatographic separation methods, seven compounds were isolated from the methanolic extract of the twigs and leaves of Knema squamulose W.J.de Wild. Their structures were elucidated as: sulfuretin (1), (-)-3,4ʹ,7-trihydroxy-3ʹ-methoxyflavan (2), 7-hydroxy-3ʹ,4ʹ-methylenedioxyflavan (3), (-)-liquiritigenin (4), eriodictyol (5), chysoeriol (6), and luteolin (7) using 1D and 2D-NMR experiments and comparison to those reported in the literature. All the isolated compounds were evaluated for their inhibitory activity against several bacterial and yeast strains.

Keywords: Knema squamulosa, Myristicaceae, Flavonoids, Antimicrobial activity.

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