Journal of Medicinal Materials, 2021, Vol. 26, No. 1+2 (pp. 90 - 94)
HEPATOPROTECTIVE EFFECT OF EXTRACTS
FROM HEDYOTIS DIFFUSA AND SCUTELLARIA BARBATA
AGAINST PARACETAMOL - INDUCED LIVER INJURY IN MICE
Duong Hong To Quyen1,3,*, Nguyen Hoang Minh2, Ha Quang Thanh2, Hoang Thi Thu Hang1,
Le Thi Thanh Nga1, Tran Vinh Nguyen1, Nguyen Thi Thu Huong2
1Hospital of Traditional Medicine in Ho Chi Minh City, Vietnam;
2Research Center of Ginseng and Medicinal Materials in Ho Chi Minh City -
National Institute of Medicinal Materials, Hanoi, Vietnam;
3University of Medicine Pham Ngoc Thach, Vietnam
*Corresponding author: email@example.com
(Received March 03rd, 2021)
Hepatoprotective Effect of Extracts from Hedyotis diffusa and Scutellaria barbata Against Paracetamol - Induced Liver Injury in Mice
The present investigation is aimed to evaluate the hepatoprotective effects of Hedyotis diffusa Willd. and Scutellaria barbata D. Don. aqueous herbal extracts (HSE) on paracetamol-induced hepatotoxicity. Paracetamol was applied to cause liver injury in Swiss albino mice. Plasma aspartate transaminase (AST), plasma alanine transaminase (ALT), hepatic malondialdehyde (MDA), and hepatic glutathione (GSH) levels were determined. HSE extract was treated at the doses of 120 mg/kg, 240 mg/kg, 360 mg/kg and 480 mg/kg in mice. Silymarin (100 mg/kg) was used as a reference drug. The results showed that the plasma AST and ALT levels increased significantly in paracetamol-treated control groups. An increase in hepatic MDA level and a decrease in hepatic GSH level were revealed in paracetamol-treated control groups, indicating oxidative damage in liver. Oral treatment with HSE prevented an increase in plasma AST, ALT, and hepatic MDA levels. In parallel, HSE extract significantly elevated hepatic GSH levels. The results showed that HSE extract might be developed as a hepatoprotective natural product with an oxidative stress-related mechanism.
Keywords: Hedyotis diffusa, Scutellaria barbata, Hepatoprotection, Paracetamol, in vivo.
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