Journal of Medicinal Materials, 2022, Vol. 27, No. 2 (pp. 101 - 106)
HEPATOPROTECTIVE EFFECT OF STANDARDIZED DRY EXTRACT FROM PHYLLANTHUS EMBLICA L. FRUITS ON ETHANOL-INDUCED HEPATOTOXICITY MODEL IN MICE AND HEPATIC STEATOSIS INHIBITION IN VITRO
Nguyen Thi Uyen1, Tran Thao Huong1, Do Thi Ha2,*, Nguyen Thuy Duong1,*
1Hanoi University of Pharmacy, Vietnam; 2National Institute of Medicinal Materials, Hanoi, Vietnam
*Corresponding authors: duongnt@hup.edu.vn and hado.nimms@gmail.com
(Received March 09th, 2022)
Summary
Hepatoprotective Effect of Standardized Dry Extract from Phyllanthus emblica L. Fruits on Ethanol-Induced Hepatotoxicity Model in Mice and Hepatic Steatosis Inhibition in vitro
The study has been undertaken to evaluate the hepatoprotective of extract from Phyllanthus emblica L. fruits using the ethanol-induced hepatotoxicity model in mice, as well as the effects on steatosis and lipid accumulation caused by fatty acid via regulation of AMPK and ACC signalling in treated HepG2 cells. The results indicated that fruits extract of P. emblica L. at doses of 500 and 1000 mg/kg body weight/day exhibited the hepatoprotective effect on ethanol-induced hepatic injury by reducing serum ASAT, ALAT activities, hepatic MDA content, as well as elevating liver S9 fraction SOD activities, GSH content in mouse model. In addition, the extract decreased significantly the fat accumulation and stimulated AMP-activated protein kinase (AMPK) signalling in treated HepG2 cells.
Keywords: Phyllanthus emblica L., Hepatoprotective effect, Ethanol, AMPK, Lipid accumulation.
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